Ribosomally synthesized peptides from natural sources
نویسندگان
چکیده
منابع مشابه
Natural Ribosomally Synthesized Circular Proteins
Over recent years several examples of natural ribosomally synthesized circular proteins from a diverse range of organisms have been discovered. They are special molecules, whose precursors must be posttranslationally modified to join the N to C termini with a head-to-tail peptide bond. This feature appears to have a range of potential advantages over their linear counterparts, since they are le...
متن کاملStructural investigation of ribosomally synthesized natural products by hypothetical structure enumeration and evaluation using tandem MS.
Ribosomally synthesized and posttranslationally modified peptides (RiPPs) are a growing class of natural products that are found in all domains of life. These compounds possess vast structural diversity and have a wide range of biological activities, promising a fertile ground for exploring novel natural products. One challenging aspect of RiPP research is the difficulty of structure determinat...
متن کاملRadical SAM Enzymes in the Biosynthesis of Ribosomally Synthesized and Post-translationally Modified Peptides (RiPPs)
Ribosomally-synthesized and post-translationally modified peptides (RiPPs) are a large and diverse family of natural products. They possess interesting biological properties such as antibiotic or anticancer activities, making them attractive for therapeutic applications. In contrast to polyketides and non-ribosomal peptides, RiPPs derive from ribosomal peptides and are post-translationally modi...
متن کاملPost-translational Introduction of d-Alanine into Ribosomally Synthesized Peptides by the Dehydroalanine Reductase NpnJ
Ribosomally synthesized peptides are generally limited to L-amino acid building blocks. Given the advantageous properties of peptides containing D-amino acids such as stabilization of certain turns and against proteolytic degradation, methods to introduce D-stereocenters are valuable. Here we report the first in vitro reconstitution and characterization of a dehydrogenase that carries out the a...
متن کاملThiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications.
Thiopeptides, with potent activity against various drug-resistant pathogens, contain a characteristic macrocyclic core consisting of multiple thiazoles, dehydroamino acids, and a 6-membered nitrogen heterocycle. Their biosynthetic pathways remain elusive, in spite of great efforts by in vivo feeding experiments. Here, cloning, sequencing, and characterization of the thiostrepton and siomycin A ...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 2014
ISSN: 0021-8820,1881-1469
DOI: 10.1038/ja.2013.138